Delivering the Future of Spatial Pathology

We've developed a high throughput spatial multiomics technology for breakthroughs in precision diagnostics and personalized medicine.

High Quality In Situ Multiomics

Delivering transcriptomics, proteomics and fH&E all in the same FFPE tissue section at subcellular resolution

G4X Spatial Multiomic Results on Head and Neck Cancer FFPE Samples

Multiomic Single-Cell Results from Head and Neck Cancer Sample Cohort on G4X
Courtesy of Dr. Shanye Yin, Assistant Professor in the Department of Pathology at Albert Einstein College of Medicine

Spatial at Scale

With unprecedented throughput, our G4X™ Spatial Sequencing Platform allows rapid, cost-effective processing of large retrospective clinical sample cohorts for AI-enabled translational insights.

Unlocking 3D Biological Insights

We're powering large-scale 3D molecular studies through reproducible, scalable multiomic performance in clinical sample types.

Single cells colored by phenotype in ROI of 3D reconstruction of 10 kidney cancer FFPE sections and 6.2 million cells from a single G4X flow cell.

Introducing G4X™

A novel high-throughput spatial multiomics platform built to power the translational breakthroughs of tomorrow.

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Driving Precision Medicine Forward, Together

"As an early access site, we had the chance to analyze hundreds of samples across every tissue type, block age, and quality. The field currently needs solutions that can directly address spatial tissue profiling cost and reduced throughput. Such flexible solutions can enable us to easily accommodate pilot projects or support large-scale consortia and clinical trials without bandwidth being a blocker. We can enable our teams and researchers to focus on the questions without worrying about how much time and resources an effort might need. Becoming a Center of Excellence for the G4X Spatial Sequencer is a milestone for the STU and will enable us to serve better our scientists in BIDMC, DF/HCC, across the State, and beyond.”

Dr. Ioannis Vlachos

Director of the Spatial Technologies Unit at Beth Israel Deaconess Medical Center and Associate Professor of Pathology at Harvard Medical School

"As part of the research activities of the VUMC GAME3D HTAN team, we are pleased to collaborate with Singular Genomics to support our research focused on generating 3D spatial multimodal datasets, with findings shared through HTAN with the broader cancer research community."

Dr. Tae Hyun Hwang

Professor of Surgery and Director of AI Research at Vanderbilt University Medical Center

“The high sample throughput and the excellent data quality that has been generated on the G4X with our bone marrow samples—notoriously a very difficult tissue type—have been impressive and have allowed us to envision much larger studies that have not been previously possible. The scale provided by the G4X promises to have a tremendous impact on expanding our understanding of the tumor microenvironment in acute myelogenous leukemia (AML) and beyond.”

Dr. Catherine Wu

Chief, Stem Cell Transplantation & Cellular Therapies, Harvard Medical School.

"The G4X data we received back from Singular on our head and neck cancer sample cohort was highly informative. Integrating transcript, protein, and fH&E data allowed us to identify cell populations and complex tumor-immune interactions with single-cell precision. Additionally, the system's robustness is confirmed as the results are fully validated by other multi-plex imaging platforms."

Dr. Shanye Yin

Assistant Professor in the Department of Pathology at Albert Einstein College of Medicine and Director of the Pathology Single-Cell core Laboratory

"The ability of the G4X platform to generate spatial multimodal data across large patient cohorts while preserving tissue architecture represents an important advance for the field. Studying cancer at this scale is essential to better understand heterogeneity, evolution, and therapeutic resistance, and ultimately to translate these insights into more precise and clinically actionable strategies.

Mariam Jamal-Hanjani, MD, PhD

Professor of Cancer Genomics and Metastasis at University College London.

"The G4X platform allowed us to analyze a large section of tissue from many samples without sacrificing on resolution and sensitivity. The ability to address multiple regions from the same biopsy greatly improved our ability to identify crucial spatial characteristics for our research questions."

Roderick L. Beijersbergen, PhD

Group Leader and Head of the NKI Robotics and Screening Center, Netherlands Cancer Institute

"The Singular G4X provides substantially increased spatial transcriptomic throughput without sacrificing precision. This expanded capacity allows us to analyze up to 32 tissue sections per slide, yielding stronger biological representation and more reliable insights."

Dan Delitto, MD, PhD

Assistant Professor of Surgery, Stanford University